Methods
3 pages in this section, most recently updated September 4, 2026.
- 01
How to read a GLP-1 trial: estimands, placebo-subtracted change and responder thresholds
The five things to check before you quote a weight-loss trial number: which estimand, what the placebo arm did, how the confidence interval reads, what a responder threshold means, and whether the endpoint was weight at all.
Updated September 4, 2026
- 02
Weight-management trials versus diabetes trials: why the same drug gets two sets of numbers
Every incretin drug has been tested in people without diabetes and in people with it, and the weight results differ by about a third. What differs in the designs, and how to read each kind.
Updated September 4, 2026
- 03
Master comparison table: 24 pivotal GLP-1 and GIP/GLP-1 trials side by side
One table for every trial digested on this site: drug, population, size, duration, primary endpoint, result with confidence interval, estimand, funding and PubMed id. Plus the interactive explorer.
Updated September 4, 2026